BMS5022 Advanced bioinformatics: efficient genome, transcriptome and proteome analysis

This unit will combine theory with practise to introduce students to techniques for rapid genome, transcriptome and proteome analysis, viz., data derived from genes and proteins. It builds on Introduction of Bioinformatics (BMS5021) to cover the foundations and research frontiers of computational biology. The unit will focus on (i) aligning and modelling genomes, (ii) gene expression and epigenomics, (iii) regulatory genomics and networks, (iii) comparative genomics and evolution, and (iv) current directions in computational biology, including single-cell and cancer genomics, population genomics, deep learning and dissecting disease mechanisms. Students will practise with influential problems in large-scale biological datasets at the level of the genome, the transcriptome and the proteome and discover the techniques to analyse these datasets.