Longitudinal and correlated data analysis

This unit will develop statistical models for longitudinal and correlated data in medical research. The concept of hierarchical data structures will be developed, together with simple numerical and analytical demonstrations of the inadequacy of standard statistical methods. Normal-theory model and statistical procedures i.e. mixed linear models are explored using SAS or Stata statistical software packages. Extension to non-normal outcomes emphasising clinical research question. Case studies contrast generalised estimating equations and generalised linear mixed models. Limitations of traditional repeated measures analysis of variance and non-exchangeable models.