Target identification and validation

This unit outlines the relationship between pathophysiology and the rational design and use of drugs.

You will be introduced to the physiological basis of disease, highlighting the causal connections between cell biochemistry, body function at the tissue, organ and system level, and human health. You will study the relationship between ligands (endogenous and exogenous) and the activation of specific cellular responses, and will explain how the selection of a relevant therapeutic target is based on a thorough understanding of biochemistry, physiology and pharmacology, and the impact of the disease process on optimal function.

Upon completing this unit, you will understand how aberrant signalling may be modified through identification and validation of appropriate protein, lipid or DNA targets, and be prepared to take these targets to the next stage in the process: drug design and optimisation.