BPS1032 Physical chemistry II: Solutions, surfaces and solids

When you finish this unit, you should be able to:

1. 1

   Analyse the physicochemical principles that underpin the important processes of pharmaceutical solids dissolving to form a solution. Describe, predict and calculate dissolution, solubility and distribution;

2. 2

   Predict and calculate the influence of functional groups and structure on solution behaviour, including colligative properties and conductivity;

3. 3

   Explain and predict the behaviour of surface-active agents at interfaces and in solution, and explain how micelles can improve drug solubilization;

4. 4

   Describe the physicochemical principles behind the formulation of liquid products, including one and two phase liquid systems, prepare and evaluate basic liquid formulations for pharmaceutical applications.

5. 5

   Describe and analyse the properties of pharmaceutical solids and semisolids, such as crystallinity, melting point, and predict their impact on solubility, stability and bioavailability;

6. 6

   Describe rheological concepts and discriminate between different rheological properties for fluids;

7. 7

   Define the role and effect of components (excipients) used to produce solution-based pharmaceutical dose forms and evaluate individual excipients, based on their physicochemical properties, in the context of a pharmaceutical product or formulation;

8. 8

   Measure fundamental solution properties through laboratory exercises and relate experimental results to theoretical concepts in the unit and from BPS1031.

9. 9

   Work effectively in a group to solve problems, present group-workshopped solutions, and manage the group to complete the task (communicating and coordinating group efforts);

10. 10

    Solve problems in a meaningful, systematic, and structured manner.