BPS3222 Synthetic strategies for drug design

In this unit, students will learn how chemical synthesis is applied to drug discovery and chemical biology. Topics will include compound library design and synthesis, mapping of structure-activity relationships, lead optimization, molecular conjugates, asymmetric synthesis and process chemistry.

These will be taught as four core topic areas: This unit will build upon earlier units in synthetic organic chemistry within B Pharm Sci, with a special emphasis on the role of chemical synthesis in drug discovery and chemical biology. This will include library design approaches for the discovery of novel bioactives and synthesis strategies in lead optimization. Students will learn about the use of conjugates in directed drug delivery and chemical biology studies. They will also learn about the specific challenges posed by the scale-up and manufacture of drugs including the asymmetric synthesis of chiral drug molecules. In laboratory classes, students will learn new and emerging techniques for use in compound library synthesis and process chemistry.