BPS2022 Drug discovery and design

When you finish this unit, you should be able to:

1. 1

   Compare historical and contemporary approaches to drug discovery in the context of the drug discovery and development pipeline

2. 2

   Describe the principles and methods of target identification and validation, assessing their importance in drug discovery

3. 3

   Differentiate between target-based and phenotypic approaches to small-molecule discovery, including the libraries and screening assays that might be suitable for each approach

4. 4

   Calculate and interpret a range of drug-likeness parameters and assess their relevance in early-stage drug development

5. 5

   Describe and use basic computational molecular modelling approaches used in structure-based drug design

6. 6

   Describe the structures, approaches to the discovery, and applications of biologics, comparing them to those of typical small molecule drugs

7. 7

   Demonstrate fundamental chemical laboratory skills relevant to drug discovery, including compound synthesis, purification, and characterization

8. 8

   Investigate and critically analyze the discovery and development of a contemporary drug in a team setting