PHR1021 How Medicines Work I

When you finish this unit, you should be able to:

1. 1

   Describe the impact that pKa and pH have on the ionisation state of a compound, and on its solubility, permeability and stability

2. 2

   Explain how chemical and thermodynamic processes influence solubility and dissolution

3. 3

   Discuss the key physicochemical properties of molecules and physiological factors that affect oral absorption

4. 4

   Predict the oral absorption characteristics of a molecule based on its key physicochemical properties

5. 5

   Describe and apply the general principles concerning the formulation of tablets and capsules

6. 6

   Explain why medicines are administered by different routes based on clinical need and molecular properties

7. 7

   Effectively communicate (orally and written) aspects of how medicines work

8. 8

   Demonstrate proficiency in fundamental pharmaceutical calculations