BPS2021 Synthetic chemistry I: structure and reactivity

When you finish this unit, you should be able to:

1. 1

   Analyse the chemical structure of pharmaceutical compounds in regard to their properties (steric, electronic, acid-base) and their reactivity using a functional group approach.

2. 2

   Formulate basic reaction mechanisms using the arrow-pushing formalism.

3. 3

   Apply kinetic and thermodynamic principles to rationalise basic reaction pathways.

4. 4

   Safely and competently perform a basic chemical synthesis, including product purification and collection of analytical data to characterise the product.

5. 5

   Describe the physical basis of selected spectroscopic techniques (primarily mass spectrometry and nuclear magnetic resonance) and explain their role in the identification of drug molecules.

6. 6

   Systematically analyse, report and interpret spectroscopic data to characterise small molecule synthesis products.

7. 7

   Clearly and accurately discuss and evaluate experimental data in a written laboratory report format.